Ipamorelin and CJC-1295 No DAC are two lab-made peptides that release growth hormone through different pituitary receptors. Related pairs of this kind released more growth hormone together than apart in animals and people. No controlled trial has tested this exact pair.
Why scientists study it
- Ipamorelin switches on GHSR-1a and CJC-1295 No DAC switches on the GHRH receptor, and in the wider GHRP plus GHRH research, hitting both at once reliably released more GH than either compound alone.
- Both peptides have short half-lives, which is meant to keep GH release in peaks and dips, closer to the body’s own pattern than the steady rise seen with the DAC version of CJC-1295 or with recombinant GH.
- Giving the two kinds of compound together has been studied in animals, and a small amount of human blood-level data exists for each one alone, but no controlled trial of this exact pair has been published.
Three studies to know
1991 · Endocrinology
Working in rats, Bowers and colleagues showed that GHRP-type peptides use their own receptor system, separate from GHRH receptors and opioid receptors. That is the basis for the more-than-additive GH response seen when a GHRP and a GHRH compound are given together. Read the paper
2006 · American Journal of Physiology: Endocrinology and Metabolism
GHRH-knockout mice given CJC-1295 once a day returned to normal growth and body makeup. Alba and colleagues took this to mean the analog can stand in for the body’s own GHRH in a controlled model of GHRH shortage. Read the paper
2009 · Growth Hormone & IGF Research
Healthy adults receiving CJC-1295 had their serum proteins measured by quantitative proteomics. Sackmann-Sala and colleagues reported changes that fit a GH/IGF-1 axis kept engaged over time, not lone spikes of GH. Read the paper
Safety and legal status
- There are animal data and limited human data for each compound alone. No peer-reviewed randomized controlled trial of ipamorelin with CJC-1295 No DAC has been completed and published.
- Not approved by the FDA, the EMA or the MHRA for any use. The World Anti-Doping Agency bans both peptides in and out of competition under class S2, which covers peptide hormones and growth factors.
- For laboratory research and test-tube use only. It is not meant for human use.
Related compounds
- Ipamorelin: Lab-made chain of five amino acids, tested mostly in animals for growth hormone release.
- CJC-1295 No DAC: Short-acting lab-made copy of GHRH, tested mostly in animals for pulses of growth hormone.
- Tesamorelin: Lab-made copy of a growth hormone signal, FDA approved to cut deep belly fat in HIV lipodystrophy.